Beilstein J. Org. Chem.2021,17, 1392–1439, doi:10.3762/bjoc.17.98
methodologies and the biological applications of double-headed nucleosides.
Keywords: acyclicdouble-headednucleosides; bicyclic double-headed nucleosides; furanosyl double-headed nucleosides; modified nucleosides; pyranosyl double-headed nucleosides; Introduction
Nucleosides are the constructional subunits
, the additional nucleobase/substituent or unsubstituted phenyl moiety/polyaromatic moiety/carbocyclic moiety/heterocyclic moiety is attached to the first nucleobase with/without a linker. Whereas, all the acyclicdouble-headednucleosides had natural nucleobases or heterocyclic moieties attached at the
double-headednucleosides was assessed through in vitro studies on Gram-positive bacteria Staphylococcus aureus, Listeria inovanii and Gram-negative bacteria Klebsiella pneumoniae, Salmonella sp., and Escherichia coli [20]. Triazolyl double-headed nucleosides showed efficacy against eosinophil-derived
PDF
Graphical Abstract
Figure 1:
Double-headed nucleosides. B1 and B2 = nucleobases or heterocyclic/carbocyclic moieties; L = linker....